ter Borg E J, Kallenberg C G
Department of Internal Medicine, University Hospital Groningen, The Netherlands.
Ann Rheum Dis. 1992 Oct;51(10):1149-51. doi: 10.1136/ard.51.10.1149.
Three patients with lupus with severe auto-immune thrombocytopenia were treated with high doses of intravenous gammaglobulin. In the patient with active disease a prolonged but partial response with respect to platelet counts was observed. In the two other patients who had no disease activity other than thrombocytopenia at the time of intravenous gammaglobulin treatment a minor (and only transient) increase in platelet counts was seen after treatment. No change in the state of disease activity nor in the levels of antinuclear antibodies, circulating immune complexes, nor complement C3/4 was observed in these three patients after treatment with intravenous gammaglobulin.
三名患有狼疮且伴有严重自身免疫性血小板减少症的患者接受了大剂量静脉注射丙种球蛋白治疗。在患有活动性疾病的患者中，观察到血小板计数有延长但部分的反应。在另外两名在静脉注射丙种球蛋白治疗时除血小板减少外无疾病活动的患者中，治疗后血小板计数有轻微（且仅为短暂）增加。在这三名患者接受静脉注射丙种球蛋白治疗后，未观察到疾病活动状态、抗核抗体水平、循环免疫复合物水平或补体C3/4有变化。
