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[大剂量静脉注射丙种球蛋白治疗因被动免疫导致血小板减少的新生儿]

[Therapy with high-dose intravenous gamma globulin in the newborn infant with thrombocytopenia from passive immunization].

作者信息

Ronconi G F, Castaman G, Fantuz E, Rodeghiero F

出版信息

Pediatr Med Chir. 1985 Jul-Aug;7(4):567-8.

PMID:2426684
Abstract

High doses of gammaglobulin intravenously have been found useful in controlling thrombocytopenia of a neonate born to a mother who developed acute idiopathic thrombocytopenic purpura during pregnancy. Administration of 0.4 gm/kg/day of intact gammaglobulin intravenously for five days was followed by dramatic rise of platelet count without any side-effect. After 1 month the platelet count was still normal. Passively-acquired immune thrombocytopenia of the newborn consequently is another indication for intravenous gammaglobulin therapy.

摘要

已发现大剂量静脉注射丙种球蛋白有助于控制孕期患急性特发性血小板减少性紫癜的母亲所生新生儿的血小板减少症。静脉注射0.4克/千克/天的完整丙种球蛋白,持续五天,随后血小板计数急剧上升,且无任何副作用。1个月后血小板计数仍正常。因此,新生儿被动获得性免疫性血小板减少症是静脉注射丙种球蛋白治疗的另一适应症。

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