Sturfelt G, Mousa F, Jonsson H, Nived O, Thysell H, Wollheim F
Department of Rheumatology, University Hospital, Lund, Sweden.
Ann Rheum Dis. 1990 Nov;49(11):939-41. doi: 10.1136/ard.49.11.939.
A 23 year old woman with systemic lupus erythematosus and antiphospholipid syndrome developed severe thrombocytopenia (5-10 X 10(9)/l) and cerebral infarction. Treatment with high doses of corticosteroids and cytostatic drugs was not effective. The condition was successfully treated only when three courses of intravenous gammaglobulin at 400 mg/kg daily was added. A clear relation was found between the immunoglobulin infusions and rising platelet counts, whereas an effect on the levels of anticardiolipin antibodies could not be recorded. The findings suggested that the mechanisms responsible may be modification and solubilisation of immune complexes or interference with anticardiolipin binding to platelet membranes, or both.
一名患有系统性红斑狼疮和抗磷脂综合征的23岁女性出现了严重的血小板减少症（5 - 10×10⁹/L）和脑梗死。高剂量皮质类固醇和细胞毒性药物治疗无效。仅在加用三个疗程、每日400mg/kg的静脉注射丙种球蛋白后，病情才得到成功治疗。发现免疫球蛋白输注与血小板计数上升之间存在明显关联，而对抗心磷脂抗体水平未发现有影响。这些发现提示，其作用机制可能是免疫复合物的修饰和溶解，或干扰抗心磷脂与血小板膜的结合，或两者兼有。
