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脑一氧化氮合酶是一种血红素蛋白。

Brain nitric oxide synthase is a haemoprotein.

作者信息

Klatt P, Schmidt K, Mayer B

机构信息

Institut für Pharmacokologie und Toxikologie, Karl-Franzens-Universität Graz, Austria.

出版信息

Biochem J. 1992 Nov 15;288 ( Pt 1)(Pt 1):15-7. doi: 10.1042/bj2880015.

DOI:10.1042/bj2880015
PMID:1280109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1132072/
Abstract

Brain nitric oxide (NO) synthase showed pyridine haemochrome spectra typical of ferroprotoporphyrin IX-containing enzymes. The haem content of purified NO synthase was in the range 0.7-0.9 mol/mol of 160 kDa subunit. In the presence of CO, NO, KCN and miconazole, the L-citrulline-forming activity of NO synthase was markedly diminished, demonstrating that enzyme-bound haem is involved in enzymic NO synthesis.

摘要

脑一氧化氮（NO）合酶呈现出含亚铁原卟啉IX的酶所特有的吡啶血红素光谱。纯化的NO合酶的血红素含量在每摩尔160 kDa亚基含0.7 - 0.9摩尔的范围内。在一氧化碳、一氧化氮、氰化钾和咪康唑存在的情况下，NO合酶的生成L - 瓜氨酸的活性显著降低，表明酶结合的血红素参与了酶促NO合成。

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本文引用的文献

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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.肝微粒体的一氧化碳结合色素。I. 其血红蛋白性质的证据。
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Soluble guanylate cyclase purified from bovine lung contains heme and copper.从牛肺中纯化得到的可溶性鸟苷酸环化酶含有血红素和铜。
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Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme.从人血小板中分离并鉴定作为细胞色素P-450酶的血栓素合酶。
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