Marin Robert S, Butters Meryl A, Mulsant Benoit H, Pollock Bruce G, Reynolds Charles F
The Intervention Research Center for the Study of Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA.
J Geriatr Psychiatry Neurol. 2003 Jun;16(2):112-6. doi: 10.1177/0891988703016002009.
Apathy and executive cognitive dysfunction (ECD) are important though conceptually different aspects of late-life depression. The primary objective of this study was to evaluate the relationship of apathy to ECD. The authors also evaluated the relationship of apathy and ECD to global cognitive impairment and word generation. Fifty-two elderly subjects with major depression and MMSE scores of 15 or greater were evaluated with apathy-related items from the Hamilton rating scale for depression (ApHRSD), the Executive Interview (EXIT), the Dementia Rating Scale (DRS), and the Controlled Oral Word Association test (COWA). ApHRSD scores were not significantly correlated with any of these variables. EXIT scores were correlated significantly with DRS and COWA. The results suggest that apathy and ECD may be independent of each other in some samples of elderly with late-life depression. Correlations may have been reduced by low variance for the variables of interest and by psychometric limitations of the ApHRSD.
冷漠和执行认知功能障碍（ECD）是老年期抑郁症重要但在概念上不同的方面。本研究的主要目的是评估冷漠与ECD之间的关系。作者还评估了冷漠和ECD与整体认知障碍及单词生成之间的关系。对52名患有重度抑郁症且简易精神状态检查表（MMSE）得分在15分及以上的老年受试者，使用汉密尔顿抑郁评定量表（ApHRSD）中与冷漠相关的项目、执行访谈（EXIT）、痴呆评定量表（DRS）以及受控口语单词联想测验（COWA）进行评估。ApHRSD得分与这些变量中的任何一个均无显著相关性。EXIT得分与DRS和COWA显著相关。结果表明，在一些老年期抑郁症患者样本中，冷漠和ECD可能相互独立。感兴趣变量的低方差以及ApHRSD的心理测量局限性可能导致了相关性降低。
