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基质金属蛋白酶：老骥伏枥，志在新途。

Matrix metalloproteinases: old dogs with new tricks.

作者信息

Somerville Robert P T, Oblander Samantha A, Apte Suneel S

机构信息

Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

出版信息

Genome Biol. 2003;4(6):216. doi: 10.1186/gb-2003-4-6-216. Epub 2003 May 29.

DOI:10.1186/gb-2003-4-6-216
PMID:12801404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC193609/
Abstract

The matrix metalloproteinase family in humans comprises 23 enzymes, which are involved in many biological processes and diseases. It was previously thought that these enzymes acted only to degrade components of the extracellular matrix, but this view has changed with the discovery that non-extracellular-matrix molecules are also substrates.

摘要

人类的基质金属蛋白酶家族由23种酶组成，这些酶参与许多生物过程和疾病。以前人们认为这些酶仅作用于降解细胞外基质的成分，但随着发现非细胞外基质分子也是底物，这种观点已经改变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e6/193609/01bf14e763e2/gb-2003-4-6-216-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e6/193609/365a1210d08b/gb-2003-4-6-216-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e6/193609/d1b811df0c41/gb-2003-4-6-216-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e6/193609/155bdd736afe/gb-2003-4-6-216-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e6/193609/01bf14e763e2/gb-2003-4-6-216-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e6/193609/365a1210d08b/gb-2003-4-6-216-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e6/193609/d1b811df0c41/gb-2003-4-6-216-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e6/193609/155bdd736afe/gb-2003-4-6-216-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90e6/193609/01bf14e763e2/gb-2003-4-6-216-4.jpg

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