Hassan Mohamed A M, Killick Stephen R
The University of Hull, Post Graduate Medical Institute and Hull & York Medical School, Hull, United Kingdom.
Fertil Steril. 2003 Jun;79 Suppl 3:1520-7. doi: 10.1016/s0015-0282(03)00366-2.
To evaluate the effect of men's age on time to pregnancy (TTP) using age at the onset of pregnancy attempts, adjusting for the confounding effects of women's age, coital frequency, and life-style characteristics.
Observational study.
Teaching hospital in Hull, United Kingdom.
PATIENT(S): Two thousand one hundred twelve consecutive pregnant women.
INTERVENTION(S): A questionnaire inquiring about TTP, contraceptive use, pregnancy planning, previous subfertility, previous pregnancies, age, and individual life-style characteristics of both partners.
MAIN OUTCOME MEASURE(S): Time to pregnancy, conception rates, and relative risk of subfecundity for men and women's age groups.
As with women's age, increasing men's age was associated with significantly rising TTP and declining conception rates. A fivefold increase in TTP occurred with men's age >45 years. Relative to men <25 years old, those >45 years were 4.6-fold and 12.5-fold more likely to have had TTP of >1 or >2 years. Restricting the analysis to partners of young women revealed similar effects of increasing men's age. Women >35 years were 2.2-fold more likely to be subfertile than women <25 years. The results were comparable, whether age at conception or at the onset of pregnancy attempts was analyzed, and they remained unchanged after adjustment for the confounding factors.
CONCLUSION(S): Evidence for and quantification of the decline in men's fertility with increasing age is provided.
以开始尝试受孕时的年龄来评估男性年龄对受孕时间（TTP）的影响，并对女性年龄、性交频率和生活方式特征的混杂效应进行校正。
观察性研究。
英国赫尔的教学医院。
2112例连续妊娠的妇女。
一份问卷，询问受孕时间、避孕措施使用情况、妊娠计划、既往生育力低下情况、既往妊娠情况、年龄以及夫妻双方的个人生活方式特征。
受孕时间、受孕率以及不同年龄组男性和女性生育力低下的相对风险。
与女性年龄一样，男性年龄增加与受孕时间显著延长和受孕率下降相关。男性年龄>45岁时，受孕时间增加了五倍。相对于25岁以下的男性，45岁以上的男性受孕时间>1年或>2年的可能性分别高4.6倍和12.5倍。将分析局限于年轻女性的伴侣时，也显示出男性年龄增加有类似影响。35岁以上的女性生育力低下的可能性比25岁以下的女性高2.2倍。无论分析受孕时还是开始尝试受孕时的年龄，结果都是可比的，并且在对混杂因素进行校正后结果保持不变。
提供了男性生育力随年龄增长而下降的证据及其量化情况。
