Menon Dev Kumar
Department of Obstetrics and Gynecology, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
Fertil Steril. 2003 Jun;79 Suppl 3:1659-61. doi: 10.1016/s0015-0282(03)00365-0.
To document for the first time the successful treatment using human chorionic gonadotropin (hCG) and human menopausal gonadotropins (hMG) of anabolic steroid-induced azoospermia that was persistent despite 1 year of cessation from steroid use.
Clinical case report.
Tertiary referral center for infertility.
PATIENT(S): A married couple with primary subfertility secondary to azoospermia and male hypogonadotropic hypogonadism. The husband was a bodybuilder who admitted to have used the anabolic steroids testosterone cypionate, methandrostenolone, oxandrolone, testosterone propionate, oxymetholone, nandrolone decanoate, and methenolone enanthate.
INTERVENTION(S): Twice-weekly injections of 10,000 IU of hCG (Profasi; Serono) and daily injections of 75 IU of hMG (Humegon; Organon) for 3 months.
MAIN OUTCOME MEASURE(S): Semen analyses, pregnancy.
RESULT(S): Semen analyses returned to normal after 3 months of treatment. The couple conceived spontaneously 7 months later.
CONCLUSION(S): Steroid-induced azoospermia that is persistent after cessation of steroid use can be treated successfully with hCG and hMG.
首次记录使用人绒毛膜促性腺激素（hCG）和人绝经期促性腺激素（hMG）成功治疗合成代谢类固醇诱导的无精子症，该无精子症在停止使用类固醇1年后仍持续存在。
临床病例报告。
三级不孕不育转诊中心。
一对已婚夫妇，因无精子症和男性低促性腺激素性性腺功能减退导致原发性亚生育力。丈夫是一名健美运动员，承认使用过合成代谢类固醇环戊丙酸睾酮、大力补、氧雄龙、丙酸睾酮、羟甲烯龙、癸酸诺龙和庚酸美替诺龙。
每周两次注射10000国际单位的hCG（普丽康；雪兰诺公司），每天注射75国际单位的hMG（贺美奇；欧加农公司），持续3个月。
精液分析、妊娠情况。
治疗3个月后精液分析恢复正常。这对夫妇在7个月后自然受孕。
停止使用类固醇后持续存在的类固醇诱导的无精子症可用hCG和hMG成功治疗。
