Avant Ross A, Charchenko Cameron M, Alom Manaf, Westerman Mary E, Maldonado Francisco, Miest Tanner, Trost Landon
Department of Urology, Mayo Clinic, Rochester, MN, USA.
Transl Androl Urol. 2018 May;7(Suppl 2):S198-S204. doi: 10.21037/tau.2018.05.05.
To describe self-reported medication patterns and fertility rates in a population of anabolic steroid (AS) users.
We reviewed data from an online survey of AS users and identified a sub-group who had attempted to achieve a pregnancy with their partners while using AS. The online survey consisted of questions addressing demographics, AS use, ancillary medications, and fertility outcomes.
A total of 97 men (of 231 total respondents) had attempted to achieve a pregnancy while taking AS and comprise the current cohort. The majority of men were 25-44 years old (63.9%), married (75.5%) and Caucasian (88.7%). Ancillary drug use was common with only 5.2% denying drug use other than ASs. The most common reported ancillary drugs were antiestrogens (89.7%) and sexual enhancement medications (SEMs) (68%). The fertility rate was 92.8%, with 82.4% achieving pregnancy within one year. Interestingly, only 13.5% sought fertility evaluation with treatment required in 8.3%. Age at initiation of AS use, maximum dosage utilized, yearly duration of supplementation, and number of years using steroids were not associated with a prolonged duration to pregnancy or decreased rate of pregnancy.
Despite continued use of ASs, this cohort's self-reported fertility rates are unexpectedly high. This is presumably related to cycling of therapy and concomitant use of fertility preserving medications.
描述合成代谢类固醇（AS）使用者群体中自我报告的用药模式和生育率。
我们回顾了对AS使用者的在线调查数据，并确定了一个在使用AS期间试图与伴侣怀孕的亚组。在线调查包括有关人口统计学、AS使用情况、辅助药物和生育结果的问题。
在总共231名受访者中，共有97名男性在服用AS期间试图怀孕，构成了当前队列。大多数男性年龄在25 - 44岁之间（63.9%），已婚（75.5%），为白种人（88.7%）。辅助药物的使用很常见，只有5.2%的人否认使用除AS以外的药物。报告最常见的辅助药物是抗雌激素药物（89.7%）和性增强药物（SEMs）（68%）。生育率为92.8%，其中82.4%在一年内怀孕。有趣的是，只有13.5%的人寻求生育评估，其中8.3%需要治疗。开始使用AS的年龄、使用的最大剂量、每年的补充持续时间以及使用类固醇的年数与怀孕时间延长或怀孕率降低无关。
尽管持续使用AS，但该队列自我报告的生育率出乎意料地高。这可能与治疗周期以及同时使用生育保护药物有关。
