Paran Ilan, Zamir Dani
Department of Plant Genetics and Breeding, Agricultural Research Organization, The Volcani Center, PO Box 6, Bet Dagan 50250, Israel.
Trends Genet. 2003 Jun;19(6):303-6. doi: 10.1016/S0168-9525(03)00117-3.
Phenotypic variation for quantitative traits results from segregation at multiple quantitative trait loci (QTL), the effects of which are modified by the internal and external environments. Because of their favorable genetic attributes (e.g. short generation time, large families and tolerance to inbreeding), plants are often used to test new concepts in quantitative trait analysis. Thus far, the molecular basis underlying allelic variation at QTL is similar to the identified variation for simple mendelian loci; namely, alterations in gene expression or protein function. Further comprehensive dissection of complex phenotypes will depend on our ability to link genetic components of the QTL variation to genomic databases.
数量性状的表型变异源于多个数量性状基因座（QTL）的分离，其效应会受到内部和外部环境的影响。由于植物具有良好的遗传特性（如世代周期短、家系大、耐近亲繁殖），因此常被用于数量性状分析新方法的测试。到目前为止，QTL等位基因变异的分子基础与已确定的简单孟德尔基因座变异相似；即基因表达或蛋白质功能的改变。对复杂表型的进一步全面剖析将取决于我们将QTL变异的遗传成分与基因组数据库相联系的能力。
