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凝血因子水平与静脉血栓栓塞症

Levels of coagulation factors and venous thromboembolism.

作者信息

Tripodi Armando

机构信息

Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milan, Italy.

出版信息

Haematologica. 2003 Jun;88(6):705-11.

PMID:12801848
Abstract

BACKGROUND AND OBJECTIVES

Altered levels of coagulation factors have been included among the abnormalities that may increase the risk of venous thromboembolism (VTE) in otherwise healthy subjects.

INFORMATION SOURCES

According to the studies that have been carried to test this hypothesis only elevated levels of factor VIII and fibrinogen emerged as independent risk factors for VTE.

STATE OF THE ART AND PERSPECTIVES

Although some data indicate that elevated levels of factor XI or IX are also determinants for VTE, this awaits confirmation.

摘要

背景与目的

凝血因子水平改变被列为可能增加健康个体静脉血栓栓塞（VTE）风险的异常情况之一。

信息来源

根据为验证这一假设而开展的研究，仅凝血因子VIII和纤维蛋白原水平升高被确认为VTE的独立危险因素。

现状与展望

尽管一些数据表明凝血因子XI或IX水平升高也是VTE的决定因素，但这一点尚待证实。

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