Nossent A Yaël, Eikenboom Jeroen C J, Bertina Rogier M
Hemostasis and Thrombosis Research Center, Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands.
Semin Hematol. 2007 Apr;44(2):77-84. doi: 10.1053/j.seminhematol.2007.01.006.
High plasma levels of several coagulation factors have been described to be associated with an increased risk of venous thrombosis. However, the mechanisms underlying these associations, as well as those involved in the regulation of plasma levels of coagulation factors, are mostly unknown. Whether these factors should be included in the workup of patients with venous thrombosis remains to be determined. In this review, we discuss the present knowledge on the effects of plasma levels of coagulation factors on the development of venous thrombosis. Furthermore, we review recent findings and ideas on the mechanisms through which elevated plasma coagulation factor levels may influence thrombosis. Finally, we enter into the matter of the possible determinants of elevated plasma levels of coagulation factors.
已有研究表明，几种凝血因子的高血浆水平与静脉血栓形成风险增加有关。然而，这些关联背后的机制以及参与凝血因子血浆水平调节的机制大多尚不清楚。这些因素是否应纳入静脉血栓形成患者的检查仍有待确定。在本综述中，我们讨论了目前关于凝血因子血浆水平对静脉血栓形成影响的知识。此外，我们回顾了关于血浆凝血因子水平升高可能影响血栓形成的机制的最新发现和观点。最后，我们探讨了血浆凝血因子水平升高的可能决定因素。
