Holinger D P, Faux S F, Shenton M E, Sokol N S, Seidman L J, Green A I, McCarley R W
Department of Psychiatry, Harvard Medical School, Brockton VAMC, MA 02401.
Electroencephalogr Clin Neurophysiol. 1992 Nov-Dec;84(6):532-7. doi: 10.1016/0168-5597(92)90042-a.
The auditory P300 evoked potential was recorded in 36 subjects: left- (LH) and right-handed (RH) schizophrenic males and LH and RH normal controls. LH and RH normals showed no asymmetry in P300 scalp topography. LH and RH schizophrenics, however, showed lateralized asymmetries in temporal scalp regions: left < right P300 voltage asymmetry in RH schizophrenics and left > right P300 voltage asymmetry in LH schizophrenics. These data suggest that the schizophrenic pathology of P300 neural generators is lateralized according to handedness and provide the first evidence that LH and RH schizophrenics can be dissociated based on left-right voltage asymmetries in P300 topography. These findings further emphasize the need for control of handedness in P300 studies of schizophrenia.
对36名受试者记录了听觉P300诱发电位：左利手（LH）和右利手（RH）的男性精神分裂症患者以及LH和RH正常对照者。LH和RH正常对照者在P300头皮地形图上未显示出不对称性。然而，LH和RH精神分裂症患者在颞部头皮区域显示出偏侧化不对称：RH精神分裂症患者中左P300电压 < 右P300电压不对称，而LH精神分裂症患者中左P300电压 > 右P300电压不对称。这些数据表明，P300神经发生器的精神分裂症病理根据利手情况而偏侧化，并提供了首个证据，即LH和RH精神分裂症患者可根据P300地形图中的左右电压不对称性进行区分。这些发现进一步强调了在精神分裂症的P300研究中控制利手情况的必要性。
