Faux S F, Torello M W, McCarley R W, Shenton M E, Duffy F H
Department of Psychiatry, Harvard Medical School, Cambridge, MA.
Biol Psychiatry. 1988 Apr 15;23(8):776-90. doi: 10.1016/0006-3223(88)90066-2.
Comparison of normal and medicated schizophrenic groups on the auditory P300 component of the event-related potential confirmed our earlier finding of a left temporal deficit in P300 amplitude in schizophrenia. A difference in P300 topography between groups was evident in both color mapping and in grand-averaged waveforms, which was statistically validated by the presence of a group-by-scalp region interaction (p less than 0.05). The left temporal area in schizophrenics was denoted as the region of greatest deficit and of maximal statistical separation (p less than 0.05) relative to normals by t statistic mapping (SPM), Hotelling's T-squared "protected" contrasts of individual scalp regions, and the relative ratio of left scalp amplitudes to right scalp amplitudes. The left temporal scalp region yielding maximal group separation in the previous study also statistically separated the schizophrenic group from the normal group. This feature correctly differentiated 9 of 11 schizophrenics and 7 of 9 controls. These findings are compatible with other histological, metabolic, and electrophysiological studies suggesting temporal lobe abnormality in schizophrenia.
对正常组和药物治疗的精神分裂症组进行事件相关电位听觉P300成分的比较，证实了我们早期的发现，即精神分裂症患者P300波幅存在左侧颞叶缺陷。在彩色图谱和总平均波形中，两组之间P300地形图的差异均很明显，通过组与头皮区域交互作用的存在得到了统计学验证（p小于0.05）。通过t统计映射（SPM）、个体头皮区域的霍特林T平方“保护”对比以及左侧头皮波幅与右侧头皮波幅的相对比率，精神分裂症患者的左侧颞叶区域被确定为相对于正常人缺陷最大且统计分离最大的区域（p小于0.05）。在前一项研究中产生最大组间分离的左侧颞叶头皮区域，在统计学上也将精神分裂症组与正常组区分开来。这一特征正确区分了11名精神分裂症患者中的9名和9名对照中的7名。这些发现与其他组织学、代谢和电生理学研究结果一致，提示精神分裂症存在颞叶异常。
