1-胡椒基哌嗪对大鼠脑中3,4-亚甲基二氧甲基苯丙胺诱导的神经毒性的拮抗作用。

Antagonism of 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rat brain by 1-piperonylpiperazine.

作者信息

Hashimoto K, Maeda H, Goromaru T

机构信息

Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan.

出版信息

Eur J Pharmacol. 1992 Sep 1;228(2-3):171-4. doi: 10.1016/0926-6917(92)90027-a.

DOI:10.1016/0926-6917(92)90027-a

PMID:1280228

Abstract

The effects of 1-piperonylpiperazine and N,alpha-dimethylpiperonylamine, which are weak inhibitors for [3H]5-hydroxytryptamine (5-HT) uptake, on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity were examined. The reductions of serotonergic parameters in the rat cerebral cortex produced by multiple administration of MDMA (10 mg/kg) were attenuated significantly by coadministration of 6-nitroquipazine (10 mg/kg), paroxetine (10 mg/kg) or 1-piperonylpiperazine (20 mg/kg), but not by N,alpha-dimethylpiperonylamine (20 mg/kg). The present data suggest that 1-piperonylpiperazine might inhibit the MDMA-induced neurotoxicity by effect(s) other than 5-HT uptake inhibition.

摘要

研究了对[3H]5-羟色胺（5-HT）摄取有微弱抑制作用的1-胡椒基哌嗪和N,α-二甲基胡椒基胺对3,4-亚甲基二氧甲基苯丙胺（摇头丸，MDMA）诱导的神经毒性的影响。多次给予MDMA（10mg/kg）导致大鼠大脑皮层中血清素能参数降低，而联合给予6-硝基喹哌嗪（10mg/kg）、帕罗西汀（10mg/kg）或1-胡椒基哌嗪（20mg/kg）可显著减弱这种降低，但联合给予N,α-二甲基胡椒基胺（20mg/kg）则无此作用。目前的数据表明，1-胡椒基哌嗪可能通过5-HT摄取抑制以外的其他作用来抑制MDMA诱导的神经毒性。