Hashimoto K, Maeda H, Goromaru T
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan.
Brain Res. 1992 Sep 11;590(1-2):341-4. doi: 10.1016/0006-8993(92)91119-y.
The neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) in rat brain was attenuated significantly by coadministration of several benzylpiperazines (p-nitrobenzylpiperazine, p-chlorobenzylpiperazine and 1-piperonylpiperazine), which were weak inhibitors for [3H]6-nitroquipazine binding to the 5-hydroxytryptamine (5-HT) transporter in rat brain. These results suggest that these benzylpiperazines may inhibit the MDMA-induced neurotoxicity by a novel neuropharmacological effect other than 5-HT uptake inhibition.
3,4-亚甲基二氧甲基苯丙胺（摇头丸）对大鼠脑的神经毒性通过联合给予几种苄基哌嗪（对硝基苄基哌嗪、对氯苄基哌嗪和1-胡椒基哌嗪）而显著减弱，这些苄基哌嗪是[3H]6-硝基喹哌嗪与大鼠脑5-羟色胺（5-HT）转运体结合的弱抑制剂。这些结果表明，这些苄基哌嗪可能通过5-HT摄取抑制以外的新型神经药理学作用来抑制摇头丸诱导的神经毒性。
