Hashimoto K
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan.
Neurosci Lett. 1993 Apr 2;152(1-2):17-20. doi: 10.1016/0304-3940(93)90472-w.
The reduction of 5-hydroxytryptamine (5-HT) in rat brain 3 h after administration of 3,4-methylenedioxymethamphetamine (MDMA) was attenuated significantly by coadministration of benzylpiperazine derivatives (p-nitrobenzylpiperazine, p-chlorobenzylpiperazine and 1-piperonylpiperazine), which were weak inhibitors of [3H]5-HT uptake into rat brain synaptosomes. However, the coadministration of desipramine and imipramine which were more potent 5-HT uptake inhibitors than these benzylpiperazines, did not attenuate the reduction of 5-HT by MDMA. These results suggest that these benzylpiperazines might inhibit the acute effects of MDMA by a novel neuropharmacological effect other than 5-HT uptake inhibition.
在给予3,4-亚甲基二氧甲基苯丙胺（摇头丸）3小时后，大鼠脑内5-羟色胺（5-HT）的减少，通过共同给予苄基哌嗪衍生物（对硝基苄基哌嗪、对氯苄基哌嗪和1-胡椒基哌嗪）而显著减弱，这些衍生物是[3H]5-HT进入大鼠脑突触体摄取的弱抑制剂。然而，共同给予比这些苄基哌嗪更强效的5-HT摄取抑制剂地昔帕明和丙咪嗪，并没有减弱摇头丸引起的5-HT减少。这些结果表明，这些苄基哌嗪可能通过5-HT摄取抑制以外的新神经药理学作用来抑制摇头丸的急性效应。
