Becker Yechiel
Department of Molecular Virology, Faculty of Medicine, The Hebrew University of Jerusalem, Israel.
Virus Genes. 2003;26(2):131-4. doi: 10.1023/a:1023479212095.
Almost 100 years elapsed after the discovery of dendritic cells in the human skin epithelium by Paul Langerhans in 1868 until the initiation of research on those cells was reinitiated. The present paper provides the milestones in the research on Langerhans/dendritic cells (LCs/DCs) between 1960 and 1989. This historical review will explain how researchers gradually discovered the role of the bone marrow-derived dendritic cells in the immune response. The paper is an appendix to the manuscript entitled: "Immunological and regulatory functions of uninfected and infected immature and mature subtypes of dendritic cells" (Virus Genes 26: 119-130, 2003).
1868年保罗·朗格汉斯在人类皮肤上皮中发现树突状细胞后，几乎过了100年，对这些细胞的研究才重新启动。本文介绍了1960年至1989年间朗格汉斯细胞/树突状细胞（LCs/DCs）研究的里程碑。这篇历史综述将解释研究人员是如何逐渐发现骨髓来源的树突状细胞在免疫反应中的作用的。本文是题为《未感染和感染的未成熟及成熟亚型树突状细胞的免疫和调节功能》（《病毒基因》26: 119 - 130, 2003年）手稿的附录。
