Real Francisco X
Unitat de Biologia Cellular i Molecular, Institut Municipal d'Investigació Mèdica, Carrer del Dr. Aiguader 80, 08003 Universitat Pompeu Fabra, Barcelona, Spain.
Gastroenterology. 2003 Jun;124(7):1958-64. doi: 10.1016/s0016-5085(03)00389-5.
Exocrine pancreas cancer has a dismal prognosis. The precise reasons accounting for its biological and clinical behavior are not known. A "catastrophe" takes place in the course of pancreas cancer development/progression so that, once it occurs, the evolution of the tumor is very rapid, leading to local invasion and metastasis. Up to now, such behavior cannot be conclusively ascribed to a single molecular event. If correct, this hypothesis has important implications regarding pancreas cancer research. Further work is warranted to examine this hypothesis and to identify the putative "catastrophic" elements participating in this tumor.
外分泌性胰腺癌的预后很差。导致其生物学和临床行为的确切原因尚不清楚。在胰腺癌发生/发展过程中会出现一种“灾难”情况，一旦发生，肿瘤的进展非常迅速，导致局部侵袭和转移。到目前为止，这种行为不能明确归因于单一分子事件。如果这一假设正确，那么对于胰腺癌研究具有重要意义。有必要开展进一步的研究来检验这一假设，并确定参与该肿瘤发生的假定“灾难性”因素。
