Mori K, Asakura S, Morikawa N, Takeyama M
Department of Clinical Pharmacy, Oita Medical University, Japan.
J Pharm Pharmacol. 1992 Oct;44(10):856-8. doi: 10.1111/j.2042-7158.1992.tb03219.x.
The effect of terfenadine on the plasma concentrations of substance P and vasoactive intestinal polypeptide (VIP) was studied in 7 healthy subjects and 8 subjects with the common cold. Before terfenadine administration, the mean plasma substance P concentration of the subjects with the common cold was significantly higher than that of the healthy subjects. The increased mean plasma substance P concentration of the subjects with the common cold was decreased after terfenadine administration. In the healthy subjects, the mean plasma substance P concentration was unchanged by terfenadine administration. The mean plasma VIP concentration of the subjects with common cold was slightly higher than that of the healthy subjects before and after terfenadine administration, with no significant difference.
在7名健康受试者和8名普通感冒受试者中研究了特非那定对P物质和血管活性肠肽（VIP）血浆浓度的影响。在给予特非那定之前，普通感冒受试者的平均血浆P物质浓度显著高于健康受试者。给予特非那定后，普通感冒受试者升高的平均血浆P物质浓度降低。在健康受试者中，给予特非那定后平均血浆P物质浓度未发生变化。普通感冒受试者的平均血浆VIP浓度在给予特非那定前后均略高于健康受试者，无显著差异。
