心肌病仓鼠衰竭心脏中的膜改变

Membrane alteration in failing hearts of cardiomyopathic hamsters.

作者信息

Singh J N, Dhalla N S, McNamara D B, Bajusz E, Jasmin G

出版信息

Recent Adv Stud Cardiac Struct Metab. 1975;6:259-68.

Abstract

Cardiomyopathic hamsters (UM-X7.1) show clinical signs of congestive heart failure and an abnormal EKG pattern. The sarcolemmal fraction obtained from the failing hearts at advanced stages of myopathy exhibited no change in the basal adenylate cyclase activity; however, the activity of this enzyme in the presence of catecholamines or NaF was lower in the failing heart sarcolemma than that in the control. The activities of Ca2+-ATPase, Mg2+-ATPase, and Na+-K+-ATPase in the failing heart sarcolemma were also less than the control values. These results suggest an association of membrane defect with heart failure.

摘要

心肌病仓鼠（UM-X7.1）表现出充血性心力衰竭的临床症状和异常的心电图模式。在肌病晚期从衰竭心脏获得的肌膜部分，基础腺苷酸环化酶活性没有变化；然而，在衰竭心脏肌膜中，儿茶酚胺或氟化钠存在时该酶的活性低于对照组。衰竭心脏肌膜中Ca2 + -ATP酶、Mg2 + -ATP酶和Na + -K + -ATP酶的活性也低于对照值。这些结果表明膜缺陷与心力衰竭有关。