Dhalla N S, McNamara D B, Anand M B
Recent Adv Stud Cardiac Struct Metab. 1976;9:1-19.
Sarcolemma consists of plasma and basement membranes and constitutes the real permeability barrier to the heart cell. It is considered to provide high electrical resistance and capacitance to heart cell and its properties are essentially similar to those of the other excitable membranes. Methods are now available for isolating heart sarcolemma with high specific activities of adenylate cyclase, (Na(+)-K(+) ATPase, Ca(++) ATPase, and Mg(++) APTase. These enzymes are considered to play an important role in heart function by regulating ion movements across sarcolemma as well as by providing signals for various metabolic processes. Sarcolemma possesses different hormone and drug receptors and any alteration in its composition could result in abnormal responses of the myocardium. We believe that heart failure is associated with sarcolemmal defects which can be detected by monitoring the activities of different membrane-bound enzymes and other related processes.
肌膜由质膜和基底膜组成，是心脏细胞真正的通透性屏障。它被认为能为心脏细胞提供高电阻和电容，其特性与其他可兴奋膜基本相似。现在有方法可用于分离具有高活性腺苷酸环化酶、（钠 - 钾）ATP酶、钙ATP酶和镁ATP酶的心脏肌膜。这些酶被认为通过调节离子跨肌膜的移动以及为各种代谢过程提供信号，在心脏功能中发挥重要作用。肌膜具有不同的激素和药物受体，其组成的任何改变都可能导致心肌的异常反应。我们认为心力衰竭与肌膜缺陷有关，可通过监测不同膜结合酶的活性和其他相关过程来检测。
