Ollier W, Thomson W
ARC Epidemiology Research Unit, University of Manchester, England.
Rheum Dis Clin North Am. 1992 Nov;18(4):741-59.
A major component of genetic susceptibility to rheumatoid arthritis (RA) appears to be explained by inheritance of HLA-DRB1 alleles, which have a conserved sequence of amino acids in the third hyper-variable region of the molecule. This "shared epitope" is found on various DR4, DR1, and DR6 variants, as well as on DR10. The evidence for this "shared epitope" in RA is examined at the population level, including how it fits in with the available epidemiologic data and RA disease severity.
类风湿关节炎（RA）遗传易感性的一个主要组成部分似乎可以通过HLA - DRB1等位基因的遗传来解释，这些等位基因在该分子的第三个高变区具有保守的氨基酸序列。这种“共享表位”存在于各种DR4、DR1和DR6变体以及DR10上。在人群水平上研究了RA中这种“共享表位”的证据，包括它如何与现有的流行病学数据和RA疾病严重程度相契合。
