Tafti M, Rondouin G, Besset A, Billiard M
Sleep and Wake Disorders Unit, Gui-de-Chauliac Hospital, Montpellier, France.
Electroencephalogr Clin Neurophysiol. 1992 Dec;83(6):339-49. doi: 10.1016/0013-4694(92)90069-t.
Sleep of 8 narcoleptic and 8 control subjects was recorded under baseline (i.e., prior wakefulness 16 h) and after 24 h without sleep. During both baseline and recovery total sleep time and stage 2 non-REM sleep were significantly decreased in narcoleptic subjects. Slow wave activity (i.e., EEG power density in the range of 0.75-4.5 Hz) decayed exponentially during baseline and after sleep deprivation in both narcoleptic and control subjects. During both baseline and recovery EEG power density in delta and sigma frequencies in non-REM sleep was enhanced in narcoleptic subjects relative to controls. In REM sleep differences in the same direction were present in delta and beta frequencies. After sleep deprivation EEG power density in non-REM sleep was elevated in delta and some higher frequencies in both patients and controls, but the response to sleep deprivation was stronger in narcoleptic subjects. These data show that in narcoleptic subjects regulatory processes underlying non-REM sleep homeostasis are operative and indicate that the response to sleep deprivation is stronger than in control subjects.
记录了8名发作性睡病患者和8名对照受试者在基线状态（即之前清醒16小时）以及24小时未睡眠后的睡眠情况。在基线和恢复阶段，发作性睡病患者的总睡眠时间和非快速眼动睡眠2期均显著减少。慢波活动（即脑电图功率密度在0.75 - 4.5赫兹范围内）在基线和睡眠剥夺后，发作性睡病患者和对照受试者均呈指数衰减。在基线和恢复阶段，发作性睡病患者非快速眼动睡眠中δ波和σ波频率的脑电图功率密度相对于对照受试者有所增强。在快速眼动睡眠中，δ波和β波频率也存在相同方向的差异。睡眠剥夺后，患者和对照受试者非快速眼动睡眠中δ波和一些较高频率的脑电图功率密度均升高，但发作性睡病患者对睡眠剥夺的反应更强。这些数据表明，发作性睡病患者非快速眼动睡眠稳态的调节过程是有效的，并且表明其对睡眠剥夺的反应比对照受试者更强。
