Seifert J, Scheuerpflug P, Zillessen K-E, Fallgatter A, Warnke A
EEG-Ep-Mapping Laboratory, Department of Child and Adolescent Psychiatry, University Hospital of Würzburg, Germany.
J Neural Transm (Vienna). 2003 Jul;110(7):821-9. doi: 10.1007/s00702-003-0818-8.
The Continuous Performance Test (CPT) is an appropriate instrument for assessment of correlates at the brain electrical activity level of attention and response to stimulant medication. The aim of the study was to confirm at the electrophysiological level the clinical effectiveness of methylphenidate (MPH) in children with attention deficit / hyperactivity disorder (ADHD); to this end, a comparative study of hyperactive and healthy control children was undertaken, employing a modified CPT test. Twenty-one channel ERPs from 17 hyperactive boys, with and without MPH treatment, and from 20 healthy control children were analyzed with reference-independent techniques. The resulting quasi-stabile microstates correspond to the time ranges of the conventional ERP components P100, P200 and P300 (with the subcomponents P3a and P3b) and could be discriminated by means of data-based segmentation. The P3a amplitudes of the hyperactive children, in each case with and without MPH medication, were compared with those of healthy controls. P3a segment amplitudes were significantly lower in non-medicated ADHD patients than in healthy children, both following positive and inhibitory stimulus conditions. A significant medication effect was detected following MPH treatment: segment 3 amplitudes in MPH-treated hyperactive children were not significantly different from those of healthy controls. MPH exerts a highly potent effect on stimulus recognition and resulting consequences. Application of the CPT-OX enables the reliable measurement of electrophysiological correlates of the clinical effectiveness of MPH under different stimulus conditions.
连续性能测试（CPT）是一种适用于评估注意力和对兴奋剂药物反应的脑电活动水平相关因素的工具。本研究的目的是在电生理水平上证实哌甲酯（MPH）对注意力缺陷/多动障碍（ADHD）儿童的临床疗效；为此，采用改良的CPT测试对多动儿童和健康对照儿童进行了一项比较研究。使用独立参考技术分析了17名接受和未接受MPH治疗的多动男孩以及20名健康对照儿童的21通道事件相关电位（ERP）。所得的准稳定微状态对应于传统ERP成分P100、P200和P300（以及子成分P3a和P3b）的时间范围，并且可以通过基于数据的分割来区分。将接受和未接受MPH药物治疗的多动儿童的P3a振幅与健康对照儿童的P3a振幅进行比较。在阳性和抑制性刺激条件下，未用药的ADHD患者的P3a节段振幅均显著低于健康儿童。MPH治疗后检测到显著的药物效应：接受MPH治疗的多动儿童的节段3振幅与健康对照儿童的节段振幅无显著差异。MPH对刺激识别及其后果具有强效作用。应用CPT-OX能够可靠地测量不同刺激条件下MPH临床疗效的电生理相关因素。
