体外受精治疗中卵巢过度反应患者的卵母细胞和胚胎质量
Oocyte and embryo quality in patients with excessive ovarian response during in vitro fertilization treatment.
作者信息
Ng Ernest Hung Yu, Lau Estella Yee Lan, Yeung William Shu Biu, Ho Pak Chung
机构信息
Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
出版信息
J Assist Reprod Genet. 2003 May;20(5):186-91. doi: 10.1023/a:1023670010031.
Abstract
PURPOSE
This study examined oocyte and embryo quality in patients having excessive ovarian responses during assisted reproduction treatment.
METHODS
Two hundred and seventy-eight women of age <40 years using a long protocol of pituitary downregulation in their first intracytoplasmic sperm injection cycle indicated for severe male factors were retrospectively evaluated. Those with serum estradiol concentration on the day of HCG <10,000, 10,000-20,000, and >20,000 pmol/L were classified into Group A, Group B, and Group C, respectively.
RESULTS
The percentage of metaphase II oocytes (85%), fertilization rate (60-66%), and distribution of blastomere number per embryo were similar among the three groups. The proportion of transferable embryos was not reduced in Group C when compared to those of Groups A and B.
CONCLUSION
Excessive ovarian response does not compromise oocyte and embryo quality in humans. Freezing of all embryos is recommended in these patients in view of associated impaired endometrial receptivity.
摘要
目的
本研究探讨了辅助生殖治疗期间卵巢反应过度患者的卵母细胞和胚胎质量。
方法
回顾性评估了278名年龄<40岁、在首次因严重男性因素而行卵胞浆内单精子注射周期中采用垂体降调节长方案的女性。将人绒毛膜促性腺激素（HCG）日血清雌二醇浓度<10,000、10,000 - 20,000和>20,000 pmol/L的患者分别分为A组、B组和C组。
结果
三组间中期II卵母细胞百分比（85%）、受精率（60 - 66%）以及每个胚胎的卵裂球数量分布相似。与A组和B组相比，C组可移植胚胎的比例并未降低。
结论
卵巢过度反应不会损害人类卵母细胞和胚胎质量。鉴于这些患者存在子宫内膜容受性受损，建议对所有胚胎进行冷冻。
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Supraphysiological estradiol levels do not affect oocyte and embryo quality in oocyte donation cycles.超生理水平的雌二醇不会影响卵母细胞捐赠周期中的卵母细胞和胚胎质量。
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Increasing levels of estradiol are deleterious to embryonic implantation because they directly affect the embryo.雌二醇水平升高对胚胎着床有害，因为它们直接影响胚胎。
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High serum oestradiol concentrations in fresh IVF cycles do not impair implantation and pregnancy rates in subsequent frozen-thawed embryo transfer cycles.新鲜体外受精周期中血清雌二醇浓度较高，并不会影响随后冻融胚胎移植周期中的着床率和妊娠率。
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