Ruebel Meghan L, Latham Keith E
Department of Animal Science, and Reproductive and Developmental Sciences Program, Michigan State University, East Lansing, Michigan.
Mol Reprod Dev. 2020 Apr;87(4):399-408. doi: 10.1002/mrd.23336. Epub 2020 Mar 22.
The oocyte is a complex cell that executes many crucial and unique functions at the start of each life. These functions are fulfilled by a unique collection of macromolecules and other factors, all of which collectively support meiosis, oocyte activation, and embryo development. This review focuses on the effects of oocyte components on developmental processes that occur after the initial stages of embryogenesis. These include long-term effects on genome function, metabolism, lineage allocation, postnatal progeny health, and even subsequent generations. Factors that regulate chromatin structure, genome programming, and mitochondrial function are elements that contribute to these oocyte functions.
卵母细胞是一种复杂的细胞，在每个生命开始时执行许多关键且独特的功能。这些功能由一系列独特的大分子和其他因子来实现，它们共同支持减数分裂、卵母细胞激活和胚胎发育。本综述聚焦于卵母细胞成分对胚胎发生初始阶段之后发生的发育过程的影响。这些影响包括对基因组功能、新陈代谢、谱系分配、产后子代健康乃至后代的长期影响。调节染色质结构、基因组编程和线粒体功能的因子是促成这些卵母细胞功能的要素。
