Martin David D, Seeger Uwe, Ranke Michael B, Grodd Wolfgang
Section for Pediatric Endocrinology, University of Tübingen, 72076 Tübingen, Germany.
AJNR Am J Neuroradiol. 2003 Jun-Jul;24(6):1177-80.
To our knowledge, this is the first report of hypogonadotropic hypogonadism, or growth hormone deficiency, in a patient without non-Pallister-Hall syndrome who had hypothalamic hamartoma diagnosed on the basis of MR imaging and MR spectroscopy findings. On short-TE proton MR spectra, the N-acetylaspartate concentration in the hamartoma was lower than that in the thalamus but similar to that in the amygdala. However, myo-inositol concentration was elevated in the hamartoma compared with that in the amygdala and thalamus. This report stresses the advantages of short-TE spectroscopy and demonstrates that regional variations in spectra should be considered when reference structures are used.
据我们所知，这是首例在无帕利斯特-霍尔综合征的患者中，基于磁共振成像（MR）和磁共振波谱（MR spectroscopy）检查结果诊断为下丘脑错构瘤的促性腺激素缺乏性性腺功能减退或生长激素缺乏症的报告。在短回波时间（TE）质子MR波谱上，错构瘤中的N-乙酰天门冬氨酸浓度低于丘脑，但与杏仁核中的浓度相似。然而，错构瘤中的肌醇浓度相比于杏仁核和丘脑有所升高。本报告强调了短TE波谱的优势，并表明在使用参考结构时应考虑波谱的区域差异。
