精氨酸酶：哮喘的标志物、效应物还是候选基因？
Arginase: marker, effector, or candidate gene for asthma?
作者信息
Vercelli Donata
机构信息
Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, Arizona 85724-5030, USA.
出版信息
J Clin Invest. 2003 Jun;111(12):1815-7. doi: 10.1172/JCI18908.
Abstract
Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.
摘要
在两种哮喘小鼠模型中对肺组织表达谱进行的微阵列分析显示，精氨酸酶I和精氨酸酶II活性水平很高，同时伴有白细胞介素-4（IL-4）和白细胞介素-13（IL-13）的过表达，这表明精氨酸途径在哮喘发病机制中至关重要。
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本文引用的文献
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J Clin Invest. 2003 Jun;111(12):1863-74. doi: 10.1172/JCI17912.
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