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本文引用的文献

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Targeted mutations in beta1,4-galactosyltransferase I reveal its multiple cellular functions.β1,4-半乳糖基转移酶I的靶向突变揭示了其多种细胞功能。
Biochim Biophys Acta. 2002 Dec 19;1573(3):258-70. doi: 10.1016/s0304-4165(02)00392-6.
2
Mouse transgenic for murine oviduct-specific glycoprotein promoter-driven simian virus 40 large T-antigen: tumor formation and its hormonal regulation.小鼠输卵管特异性糖蛋白启动子驱动猿猴病毒40大T抗原的转基因小鼠：肿瘤形成及其激素调节。
Mol Reprod Dev. 2002 Oct;63(2):168-76. doi: 10.1002/mrd.10175.
3
A testicular germ cell-associated serine-threonine kinase, MAK, is dispensable for sperm formation.一种与睾丸生殖细胞相关的丝氨酸 - 苏氨酸激酶MAK，对精子形成并非必需。
Mol Cell Biol. 2002 May;22(10):3276-80. doi: 10.1128/MCB.22.10.3276-3280.2002.
4
Characterization and biological roles of oviduct-specific, oestrogen-dependent glycoprotein.输卵管特异性雌激素依赖性糖蛋白的表征及生物学作用
Reproduction. 2002 Mar;123(3):355-62. doi: 10.1530/rep.0.1230355.
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Organization of a gene coding for an oviduct-specific glycoprotein (oviductin) in the hamster.仓鼠中编码输卵管特异性糖蛋白（输卵管蛋白）的基因结构
Mol Reprod Dev. 2000 Nov;57(3):238-46. doi: 10.1002/1098-2795(200011)57:3<238::AID-MRD5>3.0.CO;2-R.
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Effects of the porcine oviduct-specific glycoprotein on fertilization, polyspermy, and embryonic development in vitro.猪输卵管特异性糖蛋白对体外受精、多精受精及胚胎发育的影响。
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Mannose-binding molecules of rat spermatozoa and sperm-egg interaction.大鼠精子的甘露糖结合分子与精卵相互作用
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Enhancement of bovine oocyte fertilization in vitro with a bovine oviductal specific glycoprotein.用牛输卵管特异性糖蛋白增强牛卵母细胞的体外受精能力。
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The human chitotriosidase gene. Nature of inherited enzyme deficiency.人类几丁质酶基因。遗传性酶缺乏的本质。
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输卵管特异性糖蛋白基因无效突变对小鼠受精的影响。

Effect of a null mutation of the oviduct-specific glycoprotein gene on mouse fertilization.

作者信息

Araki Yoshihiko, Nohara Makoto, Yoshida-Komiya Hiromi, Kuramochi Takashi, Ito Mamoru, Hoshi Hiroyoshi, Shinkai Yoichi, Sendai Yutaka

机构信息

Department of Immunology and Parasitology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.

出版信息

Biochem J. 2003 Sep 1;374(Pt 2):551-7. doi: 10.1042/BJ20030466.

DOI:10.1042/BJ20030466
PMID:12814341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1223620/
Abstract

The mammalian fertilization process takes place in a complex microenvironment within the female genital tract. A member of the chitinase protein family, oviduct-specific glycoprotein (OGP), has been identified in oviductal fluid from various mammalian species, including humans. Although OGP is widely believed to be involved in the process of mammalian fertilization, including spermatozoon function and gamete interactions, based on experimental results obtained in vitro, its physiological significance remains controversial. The present study established OGP gene-null ( ogp (-/-)) mice, and primarily characterized their reproductive properties to study the physiological function(s) of OGP. Results obtained from studies using an in vivo or in vitro system showed that the fertility of ogp (-/-) females was within normal limits. These results indicate that OGP is not essential for the process of in vivo fertilization, at least in mice.

摘要

哺乳动物的受精过程发生在雌性生殖道内复杂的微环境中。几丁质酶蛋白家族的成员——输卵管特异性糖蛋白（OGP），已在包括人类在内的多种哺乳动物的输卵管液中被鉴定出来。尽管基于体外实验结果，人们普遍认为OGP参与了哺乳动物的受精过程，包括精子功能和配子相互作用，但其生理意义仍存在争议。本研究建立了OGP基因敲除（ogp(-/-)）小鼠，并初步表征了它们的生殖特性，以研究OGP的生理功能。使用体内或体外系统进行研究获得的结果表明，ogp(-/-)雌性小鼠的生育能力在正常范围内。这些结果表明，OGP对体内受精过程并非必不可少，至少在小鼠中是这样。