Thomson Alex M, Morris Oliver T
Department of Pharmacology, The School of Pharmacy London University, 29-39 Brunswick Square, London WC1N 1AX, UK.
J Neurocytol. 2002 Mar-Jun;31(3-5):239-46. doi: 10.1023/a:1024117908539.
In this brief review of inter-laminar synaptic connections in neocortex a case is made for the hypothesis that axons select their targets, or neurones select their inputs with great specificity. A large part of the data discussed was obtained from dual intracellular recordings in slices of adult neocortex. The neurones innervated in a given layer by a given type of axon were not found to be a random selection of the cells in that layer. Rather in a layer to layer specific fashion, certain types of target cells are densely innervated while others are not contacted or receive only weak inputs. In another layer, the same axons may select other targets.
在这篇对新皮层层间突触连接的简要综述中，提出了这样一个假说：轴突以高度特异性选择其靶标，或者神经元以高度特异性选择其输入。所讨论的数据很大一部分来自成年新皮层切片的双细胞内记录。未发现由特定类型轴突支配的某一层中的神经元是该层细胞的随机选择。相反，以层对层的特异性方式，某些类型的靶细胞被密集支配，而其他细胞则未被接触或仅接受微弱输入。在另一层中，相同的轴突可能会选择其他靶标。
