Douglas Rodney J, Martin Kevan A C
Institute of Neuroinformatics, University/ETH Zurich, Zurich 8057, Switzerland.
Annu Rev Neurosci. 2004;27:419-51. doi: 10.1146/annurev.neuro.27.070203.144152.
We explore the extent to which neocortical circuits generalize, i.e., to what extent can neocortical neurons and the circuits they form be considered as canonical? We find that, as has long been suspected by cortical neuroanatomists, the same basic laminar and tangential organization of the excitatory neurons of the neocortex is evident wherever it has been sought. Similarly, the inhibitory neurons show characteristic morphology and patterns of connections throughout the neocortex. We offer a simple model of cortical processing that is consistent with the major features of cortical circuits: The superficial layer neurons within local patches of cortex, and within areas, cooperate to explore all possible interpretations of different cortical input and cooperatively select an interpretation consistent with their various cortical and subcortical inputs.
我们探究了新皮质回路的泛化程度，即新皮质神经元及其形成的回路在多大程度上可被视为典型？我们发现，正如皮质神经解剖学家长期以来所怀疑的那样，无论在何处探寻，新皮质兴奋性神经元相同的基本层状和切向组织都很明显。同样，抑制性神经元在整个新皮质中呈现出特征性的形态和连接模式。我们提供了一个与皮质回路主要特征相符的简单皮质处理模型：皮质局部区域内以及各区域内的浅层神经元协同工作，以探索对不同皮质输入的所有可能解释，并协同选择一个与其各种皮质和皮质下输入一致的解释。
