Coscia Juliet M, Ris M Douglas, Succop Paul A, Dietrich Kim N
Children's Hospital Medical Center, Cincinnati, OH, USA.
Child Neuropsychol. 2003 Mar;9(1):10-21. doi: 10.1076/chin.9.1.10.14498.
The effect of lead exposure on cognitive growth patterns was assessed in a longitudinal study of 196 children. Performances on tests of verbal comprehension and perceptual organization (Vocabulary & Block Design, Wechsler Intelligence Scales for Children) were measured at ages 6.5, 11 and 15 years. Growth curve analyses revealed that the quadratic model best described the relationship between test scores and age. Children with higher lead levels, as measured at age 15 years, demonstrated lower verbal comprehension scores over time and greater decline in their rate of Vocabulary development at age 15 years, as compared to children with lower lead levels. Lead exposure was not significantly associated with growth in perceptual organization test scores. Socioeconomic status and maternal intelligence were statistically significantly associated with growth patterns for both test scores, independent of the effects of lead. The findings suggest that lead negatively impacts the developmental progression of specific cognitive skills from childhood through adolescence.
在一项针对196名儿童的纵向研究中，评估了铅暴露对认知生长模式的影响。在6.5岁、11岁和15岁时，对言语理解和知觉组织测试（词汇和积木图案，韦氏儿童智力量表）的表现进行了测量。生长曲线分析表明，二次模型最能描述测试分数与年龄之间的关系。与铅水平较低的儿童相比，15岁时测量的铅水平较高的儿童随着时间的推移表现出较低的言语理解分数，且15岁时词汇发展速率下降幅度更大。铅暴露与知觉组织测试分数的增长没有显著关联。社会经济地位和母亲智力在统计学上与两种测试分数的生长模式均显著相关，且独立于铅的影响。研究结果表明，铅从童年到青春期对特定认知技能的发展进程有负面影响。
