Okamoto Hiroyuki, Mizuno Kana, Horio Takeshi
Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan.
Acta Derm Venereol. 2003;83(3):171-4. doi: 10.1080/00015550310007148.
Multinucleated giant cells are characteristic of a monocyte-macrophage lineage in sarcoidosis and consist of two types of cells: Langhans-type with an arcuate arrangement of nuclei and a foreign-body type with random arrangement of nuclei. To compare these cells in the cutaneous lesions of sarcoidosis, we histologically and immunohistologically examined multinucleated giant cells in 25 scar infiltrations (cutaneous sarcoidosis with foreign bodies) and 30 cutaneous lesions of sarcoidosis without foreign bodies. Regardless of the presence or absence of foreign bodies, the cutaneous lesions had both types of multinucleated giant cells, usually with a predominance of the Langhans-type, although the numbers of total multinucleated giant cells were higher in scar infiltrations than in cutaneous sarcoidosis without foreign bodies, suggesting that their frequency is influenced by the microenvironment in sarcoidal lesions such as the presence of foreign bodies. Immunohistochemical studies using surface antigens of monocyte-macrophage lineage cells and adhesion molecules indicated that both types of multinucleated giant cells are formed from monocytes rather than tissue macrophages and are phenotypically the same cells with different distributions of nuclei.
多核巨细胞是结节病中单核细胞-巨噬细胞谱系的特征性细胞，由两种类型的细胞组成：核呈弓形排列的朗汉斯型和核随机排列的异物型。为了比较结节病皮肤病变中的这些细胞，我们对25例瘢痕浸润（伴有异物的皮肤结节病）和30例无异物的结节病皮肤病变中的多核巨细胞进行了组织学和免疫组织学检查。无论有无异物，皮肤病变中均有这两种类型的多核巨细胞，通常以朗汉斯型为主，尽管瘢痕浸润中多核巨细胞的总数高于无异物的皮肤结节病，这表明它们的频率受结节病病变中的微环境影响，如异物的存在。使用单核细胞-巨噬细胞谱系细胞表面抗原和黏附分子的免疫组织化学研究表明，两种类型的多核巨细胞均由单核细胞而非组织巨噬细胞形成，并且在表型上是具有不同核分布的相同细胞。
