van der Rhee H J, Hillebrands W, Daems W T
Arch Dermatol Res. 1978;263(1):13-21.
Granulomas were induced in rats by subcutaneous implantation of pieces of Melinex plastic into the dorsum. The pieces of Melinex were removed at intervals varying from 16 h to 14 days, and the adherent cells were studied morphologically and quantitatively. Giant cell formation started about 32 h after implantation. The first giant cells to appear were of the Langhans type. Two days after implantation, most of the giant cells are still Langhans-type cells. A few giant cells of the foreign-body type and transition forms between the Langhans and foreign-body types are also present. From the third day on, the foreign-body type gradually becomes predominant. Independent of the duration of implantation, giant cells with 3, 4, or 5 nuclei are virtually without exception of the Langhans type. The higher the number of nuclei between 6 and 30, the more cells are of the foreign-body type. Giant cells with 30 or more nuclei are all foreign-body type. The findings are discussed in the light of current knowledge concerning giant cell formation. It is concluded that under the present experimental conditions, Langhans-type giant cells are the precursors of foreign-body-type giant cells.
通过将美耐皿塑料片皮下植入大鼠背部诱导肉芽肿形成。在16小时至14天不等的时间间隔后取出美耐皿片，并对贴壁细胞进行形态学和定量研究。植入后约32小时开始出现巨细胞形成。最早出现的巨细胞是朗汉斯型。植入后两天，大多数巨细胞仍是朗汉斯型细胞。也存在一些异物型巨细胞以及朗汉斯型和异物型之间的过渡形式。从第三天开始，异物型逐渐占主导。无论植入持续时间如何，具有3、4或5个核的巨细胞几乎无一例外都是朗汉斯型。核数在6至30之间越高，异物型细胞就越多。具有30个或更多核的巨细胞都是异物型。根据目前关于巨细胞形成的知识对这些发现进行了讨论。得出的结论是，在当前实验条件下，朗汉斯型巨细胞是异物型巨细胞的前体。
