van der Rhee H J, Hillebrands W, Daems W T
Arch Dermatol Res. 1978 Sep 28;263(1):13-21.
Granulomas were induced in rats by subcutaneous implantation of pieces of Melinex plastic into the dorsum. The pieces of Melinex were removed at intervals varying from 16h to 14 days, and the adherent cells were studied morphologically and quantitatively. Giant cell formation started about 32h after implantation. The first giant cells to appear were of the Langerhans type. Two days after implantation, most of the giant cells are still Langhans-type cells. A few giant cells of the foreign-body type and transition forms between the Langhans and foreign-body types are also present. From the third day on, the foreign-body type gradually becomes predominant. Independent of the duration of implantation, giant cells with 3, 4, or 5 nuclei are virtually without exception of the Langhans type. The higher the number of nuclei between 6 and 30, the more cells are of the foreign-body type. Giant cells with 30 or more nuclei are all foreign-body type. The findings are discussed in the light of current knowledge concerning giant cell formation. It is concluded that under the present experimental conditions, Langhans-type giant cells are the precursors of foreign-body-type giant cells.
通过将Melinex塑料片皮下植入大鼠背部诱导肉芽肿形成。在16小时至14天不等的时间间隔后取出Melinex片，对贴附细胞进行形态学和定量研究。植入后约32小时开始形成巨细胞。最早出现的巨细胞是朗汉斯型。植入后两天，大多数巨细胞仍是朗汉斯型细胞。也存在一些异物型巨细胞以及朗汉斯型和异物型之间的过渡形式。从第三天开始，异物型逐渐占主导。与植入持续时间无关，具有3、4或5个核的巨细胞几乎无一例外是朗汉斯型。核数在6至30之间越高，异物型细胞越多。具有30个或更多核的巨细胞均为异物型。根据当前有关巨细胞形成的知识对这些发现进行了讨论。得出的结论是，在目前的实验条件下，朗汉斯型巨细胞是异物型巨细胞的前体。
