Bryld Lars Erik, Agner Tove, Menné Torkil
Department of Dermatology, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark.
Acta Derm Venereol. 2003;83(3):186-8. doi: 10.1080/00015550310007184.
The aetiology of vesicular eruptions on the palms and on the sides of the fingers (pompholyx) is unclear. The present study was undertaken to establish whether tinea pedis, atopic dermatitis or nickel allergy is a risk factor for development of vesicular eruptions. Three-hundred-and-ninety-eight individuals (included from an ongoing population study on hand eczema in twins) were included. A history of previous hand eczema and atopic dermatitis was taken, and a clinical examination including a patch test with nickel was performed. A test sample for tinea pedis was taken from the fourth interdigital space on the right foot. The relative risk for vesicular eruptions present in individuals with tinea pedis was 3.58 (confidence limits 1.19-10.82, p < 0.05). For individuals with atopic dermatitis, relative risk was 1.44 (confidence limits 0.34-6.07, n.s.) and for those with nickel allergy it was 0.45 (confidence limits 0.06-3.36, n.s.). A relationship between tinea pedis and vesicular eruptions on the hands was statistically confirmed in the present study. In this part of the population study material, no association with atopic dermatitis or nickel allergy was observed.
手掌和手指侧面水疱性皮疹（汗疱疹）的病因尚不清楚。本研究旨在确定足癣、特应性皮炎或镍过敏是否是水疱性皮疹发生的危险因素。研究纳入了398名个体（来自一项正在进行的双胞胎手部湿疹人群研究）。记录既往手部湿疹和特应性皮炎病史，并进行包括镍斑贴试验在内的临床检查。从右脚第四趾间间隙采集足癣检测样本。足癣患者出现水疱性皮疹的相对风险为3.58（置信区间1.19 - 10.82，p < 0.05）。特应性皮炎患者的相对风险为1.44（置信区间0.34 - 6.07，无统计学意义），镍过敏患者的相对风险为0.45（置信区间0.06 - 3.36，无统计学意义）。本研究在统计学上证实了足癣与手部水疱性皮疹之间的关系。在该人群研究材料的这一部分中，未观察到与特应性皮炎或镍过敏的关联。
