Mathieu David, Beaudry Mathieu, Martin René, McLelland Hans, Robert Bruno, Kenny Brendan
Department of Neurosurgery, Centre Hospitalier Universitaire de Sherbrooke, Québec, Canada.
J Neurosurg. 2003 Jun;98(6):1194-7. doi: 10.3171/jns.2003.98.6.1194.
The authors conducted a double-blind prospective randomized study to determine whether infiltration of Mayfield skull-pin sites with 0.5% bupivacaine, compared with placebo, would prevent hemodynamic stimulation, thus allowing for a reduction in the quantity of anesthetic agents required.
Thirty patients were randomized into two groups. There was a significant increase in blood pressure (mean systolic blood pressure 10 mm Hg, p = 0.003) in patients in the placebo group compared with that in patients in the bupivacaine group 1 minute after securing the head holder.
The local administration of bupivacaine for anesthetic purposes before skull-pin application may prevent potentially hazardous hemodynamic stimulation.
作者进行了一项双盲前瞻性随机研究，以确定与安慰剂相比，用0.5%布比卡因浸润梅菲尔德颅骨针固定点是否能预防血流动力学刺激，从而减少所需麻醉剂的用量。
30例患者被随机分为两组。与布比卡因组患者相比，安慰剂组患者在固定头架后1分钟时血压显著升高（平均收缩压升高10 mmHg，p = 0.003）。
在应用颅骨针之前局部使用布比卡因进行麻醉可能预防潜在的有害血流动力学刺激。
