Epstein J I, Fynheer J
Department of Pathology, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21205.
Hum Pathol. 1992 Dec;23(12):1321-5. doi: 10.1016/0046-8177(92)90049-9.
Numerous reports have claimed that because acidic mucin is absent in benign prostatic glands and is present in some prostatic adenocarcinomas, this stain may be an adjunctive aid in the diagnosis of adenocarcinoma of the prostate. However, adenosis that mimics low-grade adenocarcinoma has not been evaluated to date. We studied 28 foci of adenosis for the presence of high iron diamine-alcian blue (HID-AB). Fifteen foci of adenosis (54%) showed strong staining for HID-AB; staining was diffuse in 11 cases and focal in four cases. An additional two cases (7%) showed equivocal staining. The remaining 11 cases (39%) lacked positivity. All cases of adenosis were verified with immunohistochemistry for keratin 903, a basal cell-specific antibody. This study demonstrates the limited use of acid mucin staining in the diagnosis of adenocarcinoma. The finding of HID-AB positivity in occasional isolated benign small prostatic glands within hyperplastic nodules suggests that acid mucin secretion may be a reflection of gland size or proliferation rather than evidence that adenosis is related to adenocarcinoma of the prostate.
众多报告称，由于良性前列腺腺体内不存在酸性黏蛋白，而在一些前列腺腺癌中存在，因此这种染色可能有助于前列腺腺癌的诊断。然而，迄今为止，尚未对酷似低级别腺癌的腺病进行评估。我们研究了28个腺病病灶中的高铁二胺-阿尔辛蓝（HID-AB）情况。15个腺病病灶（54%）HID-AB染色呈强阳性；11例为弥漫性染色，4例为局灶性染色。另外2例（7%）染色结果不明确。其余11例（39%）无阳性表现。所有腺病病例均通过免疫组织化学检测基底细胞特异性抗体角蛋白903进行了验证。本研究表明酸性黏蛋白染色在前列腺腺癌诊断中的应用有限。在增生性结节内偶尔孤立的良性小前列腺腺体内发现HID-AB阳性，提示酸性黏蛋白分泌可能反映腺体大小或增殖情况，而非腺病与前列腺腺癌相关的证据。
