Krawczuk-Rybak M, Grygorczuk S, Urban M
II Klinika Chorób Dzieci AM, 15-274 Białystok.
Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 1999;5(1):21-7.
type I diabetes mellitus is considered as an autoimmune disease and is often associated with other diseases of that etiology. The genetic susceptibility to autoimmune disorders causes type I diabetes to occur more frequently in relatives of the diabetic patients.
To evaluate the prevalence of type I diabetes and other autoimmune diseases in families of the children with type I diabetes.
The prevalence of type I diabetes mellitus and other autoimmune endocrinopathies was evaluated in I, II and III degree relatives of 155 children with type I diabetes mellitus and 90 control children.
It was observed that: 1) diabetes mellitus occurred more often in relatives of diabetic children (in 22 families - 14.2%) in comparison with the control group (in 2 families - 2.2%); 2) other autoimmune diseases occurred frequently in families of diabetic children and they affected 2 or more members of one family more often than in the control group (18 families vs 4); 3) rheumatoid arthritis occurred more frequently in families of diabetic children.
The familial prevalence of type I diabetes mellitus and the tendency to more frequent prevalence of other autoimmune diseases in families of diabetic children was confirmed.
1型糖尿病被认为是一种自身免疫性疾病，常与其他该病因的疾病相关。自身免疫性疾病的遗传易感性导致1型糖尿病在糖尿病患者亲属中更频繁发生。
评估1型糖尿病患儿家庭中1型糖尿病及其他自身免疫性疾病的患病率。
对155例1型糖尿病患儿和90例对照儿童的I、II和III级亲属中1型糖尿病及其他自身免疫性内分泌病的患病率进行评估。
观察到：1）与对照组（2个家庭，占2.2%）相比，糖尿病患儿亲属中糖尿病发生更频繁（22个家庭，占14.2%）；2）糖尿病患儿家庭中其他自身免疫性疾病发生频繁，且一个家庭中2名或更多成员受影响的情况比对照组更常见（18个家庭对4个家庭）；3）类风湿关节炎在糖尿病患儿家庭中发生更频繁。
证实了1型糖尿病的家族患病率以及糖尿病患儿家庭中其他自身免疫性疾病更频繁发生的倾向。
