Warburton E Clea, Koder Timothy, Cho Kwangwook, Massey Peter V, Duguid Gail, Barker Gareth R I, Aggleton John P, Bashir Zafar I, Brown Malcolm W
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, BS8 1 TD, Bristol, United Kingdom.
Neuron. 2003 Jun 19;38(6):987-96. doi: 10.1016/s0896-6273(03)00358-1.
We establish the importance of cholinergic neurotransmission to both recognition memory and plasticity within the perirhinal cortex of the temporal lobe. The muscarinic receptor antagonist scopolamine impaired the preferential exploration of novel over familiar objects, disrupted the normal reduced activation of perirhinal neurones to familiar compared to novel pictures, and blocked production of long-term depression (LTD) but not long-term potentiation (LTP) of synaptic transmission in perirhinal slices. The consistency of these effects across the behavioral, systems, and cellular levels of analysis provides strong evidence for the involvement of cholinergic mechanisms in synaptic plastic processes within perirhinal cortex that are necessary for recognition memory.
我们证实了胆碱能神经传递对于颞叶内嗅周皮质的识别记忆和可塑性均具有重要意义。毒蕈碱受体拮抗剂东莨菪碱损害了对新物体相较于熟悉物体的优先探索，破坏了嗅周神经元对熟悉图片相较于新图片正常的激活降低，并且阻断了嗅周脑片突触传递的长时程抑制（LTD）而非长时程增强（LTP）。这些效应在行为、系统和细胞分析水平上的一致性，为胆碱能机制参与嗅周皮质内对识别记忆至关重要的突触可塑性过程提供了有力证据。
