Ma Zuwei, Gao Changyou, Gong Yihong, Shen Jiacong
Department of Polymer Science and Engineering, Zhejiang University, 310027, Hangzhou, China.
Biomaterials. 2003 Sep;24(21):3725-30. doi: 10.1016/s0142-9612(03)00247-3.
Hydrophilic groups, i.e. hydroxyl (-OH), carboxyl (-COOH) or amide (-CONH(2)) were introduced onto the poly-L-lactic acid (PLLA) membrane surfaces via the photo-induced grafting copolymerization of the corresponding monomers, i.e. hydroxyethyl methacrylate, methacrylic acid or acrylamide, respectively. Chondrocyte culture was used to study the correlation between the cell behaviors and the hydrophilic functional groups. The results showed that the cytocompatibility of the PLLA membranes with hydroxyl or amide groups on the surface was greatly improved compared to that of the original PLLA membrane. However, the PLLA membrane with carboxyl groups on the surface had even worse cytocompatibility though possessed a similar hydrophilicity.
通过相应单体（即分别为甲基丙烯酸羟乙酯、甲基丙烯酸或丙烯酰胺）的光诱导接枝共聚反应，将亲水基团，即羟基（-OH）、羧基（-COOH）或酰胺基（-CONH₂）引入聚-L-乳酸（PLLA）膜表面。采用软骨细胞培养来研究细胞行为与亲水性官能团之间的相关性。结果表明，与原始PLLA膜相比，表面带有羟基或酰胺基的PLLA膜的细胞相容性得到了极大改善。然而，表面带有羧基的PLLA膜尽管具有相似的亲水性，但其细胞相容性却更差。
