Levendoglu Funda, Temizhan Ahmet, Ugurlu Hatice, Ozdemir Ayse, Yazici Mehmet
Department of Physical Medicine and Rehabilitation, Meram Medical School of Selcuk University, Meram-Konya, Turkey.
Rheumatol Int. 2004 May;24(3):141-6. doi: 10.1007/s00296-003-0342-z. Epub 2003 Jun 19.
The aim of the present study was to evaluate cardiac involvement in patients with active rheumatoid arthritis (RA).
Forty patients with active RA participated. All were submitted to standard Doppler echocardiography and myocardial performance index (MPI) grading.
There were left and right ventricular diastolic function abnormalities in RA patients. Left ventricular MPI was also significantly higher than in controls ( P<0.05). A relationship was found between left ventricular early diastolic (E)/atrial (A) flow velocities (E/A ratio), isovolumic relaxation time (IRT), and disease duration ( r=-0.47 and P=0.002, r=0.618 and P=0.000, respectively).
Diastolic function was impaired in both ventricles in patients with active RA. There was a direct relationship between some of the parameters of left ventricular diastolic function and disease duration as well. These findings suggest a subclinical myocardial involvement in RA patients.
本研究旨在评估活动期类风湿关节炎（RA）患者的心脏受累情况。
40例活动期RA患者参与研究。所有患者均接受标准多普勒超声心动图检查及心肌性能指数（MPI）分级。
RA患者存在左、右心室舒张功能异常。左心室MPI也显著高于对照组（P<0.05）。发现左心室舒张早期（E）/心房（A）血流速度（E/A比值）、等容舒张时间（IRT）与病程之间存在相关性（r分别为-0.47，P=0.002；r为0.618，P=0.000）。
活动期RA患者双心室舒张功能均受损。左心室舒张功能的某些参数与病程之间也存在直接关系。这些发现提示RA患者存在亚临床心肌受累。
