Lindenberg Th, Horn F K, Korth M
Augenklinik mit Poliklinik der Friedrich-Alexander-Universität Erlangen-Nuremberg, Erlangen.
Ophthalmologe. 2003 Jun;100(6):453-8. doi: 10.1007/s00347-002-0759-x.
This study was designed to answer the question of whether multifocal steady-state pattern-reversal electroretinography (ERG) is capable of detecting glaucomatous visual field defects.
Sixteen patients (28 eyes) and ten normal subjects (20 eyes) were examined. Multifocal pattern ERGs were recorded with the RETIscan system and DTL electrodes. We stimulated with a steady-state checkerboard pattern reversal (three reversals during 171 ms sweep length, congruent with 17.5 reversals/s). The multifocal pattern ERG amplitudes were evaluated using discrete Fourier transformation (DFT) across three reversals. In cases of advanced glaucoma, the DFT-calculated amplitudes were combined in hemispheres and checked for correlations with corresponding visual field defects. In all binocularly examined persons, side comparisons ("worse" eye vs "better" eye), and interindividual comparisons (glaucoma vs normal) were carried out.
In interindividual comparisons and interocular side comparisons, significant amplitude reductions of the "worse" eyes were seen in the foveal records. No topographical correlation between multifocal pattern ERG amplitudes and visual field defects could be found.
In glaucomatous visual field defects, multifocal steady-state pattern-reversal ERG using the present stimulation was significantly reduced in its foveal records but seems to be incapable of detecting them topographically.
本研究旨在回答多焦点稳态图形视网膜电图（ERG）是否能够检测青光眼性视野缺损这一问题。
对16例患者（28只眼）和10名正常受试者（20只眼）进行检查。使用RETIscan系统和DTL电极记录多焦点图形视网膜电图。我们用稳态棋盘格图形反转进行刺激（在171毫秒扫描长度内有三次反转，相当于17.5次反转/秒）。使用离散傅里叶变换（DFT）对三次反转的多焦点图形视网膜电图振幅进行评估。在晚期青光眼病例中，将DFT计算出的振幅在半球中合并，并检查与相应视野缺损的相关性。在所有双眼检查的受试者中，进行了双眼比较（“较差”眼与“较好”眼）以及个体间比较（青光眼患者与正常人）。
在个体间比较和眼间双侧比较中，在中央凹记录中发现“较差”眼的振幅有显著降低。未发现多焦点图形视网膜电图振幅与视野缺损之间存在地形学相关性。
在青光眼性视野缺损中，使用当前刺激的多焦点稳态图形反转视网膜电图在中央凹记录中显著降低，但似乎无法从地形学上检测到这些缺损。
