Wanger P, Persson H E
Invest Ophthalmol Vis Sci. 1983 Jun;24(6):749-53.
Pattern-reversal and flash electroretinograms (ERG) and oscillatory potentials (OP) were recorded from 11 patients with unilateral glaucoma. All glaucomatous eyes had reduced amplitudes both compared to the opposite eye in the same patient and to reference values. In 10 of the 11 cases this reduction was below the level of normal variation. The difference in pattern-reversal ERG amplitude means from glaucomatous and opposite eyes was statistically significant. No differences were observed in flash ERGs or OPs. The histopathologic correlate to the visual field defects in glaucoma is retinal ganglion cell degeneration. The present electrophysiologic findings support the view, based on results from animal experiments, that the pattern-reversal ERG reflects ganglion cell activity.
对11例单侧青光眼患者进行了图形翻转视网膜电图（ERG）、闪光视网膜电图及振荡电位（OP）记录。所有青光眼患眼与同患者的对侧眼相比以及与参考值相比，振幅均降低。11例中的10例，这种降低低于正常变异水平。青光眼患眼与对侧眼图形翻转ERG振幅均值的差异具有统计学意义。闪光ERG或振荡电位未观察到差异。青光眼视野缺损的组织病理学相关改变是视网膜神经节细胞变性。基于动物实验结果，目前的电生理研究结果支持图形翻转ERG反映神经节细胞活性这一观点。
