类风湿关节炎患者体内的抗乳铁蛋白抗体与血管炎相关。
Antilactoferrin antibodies in patients with rheumatoid arthritis are associated with vasculitis.
作者信息
Coremans I E, Hagen E C, Daha M R, van der Woude F J, van der Voort E A, Kleijburg-van der Keur C, Breedveld F C
机构信息
Department of Rheumatology, University Hospital, Leiden, The Netherlands.
出版信息
Arthritis Rheum. 1992 Dec;35(12):1466-75. doi: 10.1002/art.1780351210.
OBJECTIVE
To determine the occurrence of antineutrophil cytoplasmic antibodies (ANCA) and the specificity of these antibodies (Ab) in serum from patients with rheumatoid arthritis (RA) and patients with rheumatoid arthritis complicated by vasculitis (rheumatoid vasculitis [RV]).
METHODS
ANCA was detected with an indirect immunofluorescence test on ethanol-fixed granulocytes. Ab against the cytoplasmic antigens proteinase-3, elastase, lactoferrin (LF), and myeloperoxidase were measured by enzyme-linked immunosorbent assay.
RESULTS
ANCA were found in the serum of 43% of 49 patients with RV and in 36% of 50 patients with RA. Anti-LF Ab occurred more frequently in RV patients (45%) than in RA patients (4%), whereas reactivity against the other cytoplasmic antigens did not differe significantly between these groups.
CONCLUSION
Anti-LF Ab in serum of patients with RA may be useful in the diagnosis of vasculitis in RA.
目的
确定类风湿关节炎（RA）患者及合并血管炎的类风湿关节炎患者（类风湿性血管炎[RV]）血清中抗中性粒细胞胞浆抗体（ANCA）的发生率及其抗体（Ab）的特异性。
方法
采用间接免疫荧光试验在乙醇固定的粒细胞上检测ANCA。通过酶联免疫吸附测定法检测针对胞浆抗原蛋白酶-3、弹性蛋白酶、乳铁蛋白（LF）和髓过氧化物酶的抗体。
结果
49例RV患者中有43%的血清中检测到ANCA，50例RA患者中有36%的血清中检测到ANCA。抗LF抗体在RV患者（45%）中比在RA患者（4%）中更频繁出现，而这些组之间针对其他胞浆抗原的反应性无显著差异。
结论
RA患者血清中的抗LF抗体可能有助于RA血管炎的诊断。
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