Klapdor R, Bahlo M, Babinski A
Medical Department, Jerusalem Hospital, ZeTDT GmbH, Hamburg, Germany.
Anticancer Res. 2003 Mar-Apr;23(2A):845-50.
We report on 4 cancer patients with transient unspecific elevations of the serum tumor markers CA 19-9, CEA, CA 125 and CA 72-4, respectively. In one patient cholangitis due to biliary obstruction induced a significant transient increase of CA 19-9, in another patient HUS, probably as a severe complication after Mitomycin-C + Gemcitabine therapy resulted in a significant increase of serum CA 125. One patient demonstrated an extensively elevated and inexplicable serum CA 19-9 concentration (9450 u/ml) during a period of abdominal pain with continuous decrease and finally normalization within the following 5 years. Also inexplicable is an unexpected remittent increase of serum CA 72-4 in the course of chemotherapy after gastrectomy for gastric carcinoma. The presented data underline the necessity of interpreting serum courses of tumor markers only in the light of all available clinical data, imaging data and other laboratory tests in order to avoid misinterpretations.
我们报告了4例癌症患者，其血清肿瘤标志物CA 19-9、癌胚抗原（CEA）、CA 125和CA 72-4分别出现短暂的非特异性升高。1例患者因胆管阻塞引起的胆管炎导致CA 19-9显著短暂升高，另1例患者患溶血尿毒综合征（HUS），可能是丝裂霉素C+吉西他滨治疗后的严重并发症，导致血清CA 125显著升高。1例患者在腹痛期间血清CA 19-9浓度广泛升高且无法解释（9450 u/ml），随后5年内持续下降并最终恢复正常。同样无法解释的是，1例胃癌患者在胃切除术后化疗过程中血清CA 72-4意外出现间歇性升高。所呈现的数据强调，仅根据所有可用的临床数据、影像学数据和其他实验室检查来解读肿瘤标志物的血清变化过程很有必要，以避免误解。
