类花生酸对小鼠巨噬细胞系J774中一氧化氮合酶诱导的调节作用
Modulation of the induction of nitric oxide synthase by eicosanoids in the murine macrophage cell line J774.
作者信息
Marotta P, Sautebin L, Di Rosa M
机构信息
Department of Experimental Pharmacology, University of Naples Federico II, Italy.
出版信息
Br J Pharmacol. 1992 Nov;107(3):640-1. doi: 10.1111/j.1476-5381.1992.tb14499.x.
Abstract
The effect of eicosanoids on the induction of nitric oxide synthase in the murine macrophage cell line J774 has been studied. We found that prostaglandin E2 (PGE2) and iloprost (a stable analogue of prostacyclin) both at nanomolar concentrations inhibited the lipopolysaccharide stimulated induction of NO synthase. In contrast PGF2 alpha, U46619, a stable analogue of thromboxane A2, leukotrienes B4 and C4 had no effect. These data demonstrate that the L-arginine: NO pathway in macrophages may be modulated by prostanoids.
摘要
已研究了类花生酸对小鼠巨噬细胞系J774中一氧化氮合酶诱导的影响。我们发现，纳摩尔浓度的前列腺素E2（PGE2）和伊洛前列素（前列环素的稳定类似物）均抑制脂多糖刺激的一氧化氮合酶诱导。相比之下，前列腺素F2α、血栓素A2的稳定类似物U46619、白三烯B4和C4则没有作用。这些数据表明，巨噬细胞中的L-精氨酸：一氧化氮途径可能受前列腺素调节。
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