Magin M N, O'Connor P J, Craig A W, Margison G P
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975 Nov 25;84(3):217-22. doi: 10.1007/BF00312243.
An examination was made of the effect of treatment with methylating agents of varying carcinogenic potency and with stress inducing hormones upon DNA synthesis in the resting liver of the rat. With the methylating agents an early stimulation of DNA synthesis was observed, but this was depressed below the control levels at later times and with higher doses; hormone administration also resulted in a depression of DNA synthesis but, without any initial stimulation at the dosage employed. Under conditions of induced stress it was found that the extent of reaction of N-methyl-N-nitrosourea with cellular macromolecules was enhanced. This appeared to be a general effect upon the liver cell since both DNA and rRNA were affected in a similar manner.
研究了不同致癌效力的甲基化剂以及应激诱导激素对大鼠静息肝脏中DNA合成的影响。使用甲基化剂时，观察到DNA合成早期受到刺激，但在后期及较高剂量下，其低于对照水平；给予激素也导致DNA合成受到抑制，但在所采用的剂量下没有任何初始刺激。在诱导应激条件下，发现N-甲基-N-亚硝基脲与细胞大分子的反应程度增强。这似乎是对肝细胞的普遍影响，因为DNA和rRNA都受到了类似的影响。
