Marazziti D, Ambrogi F, Vanacore R, Mignani V, Savino M, Palego L, Cassano G B, Akiskal H S
Department of Psychiatry, University of Pisa, Italy.
Neuropsychobiology. 1992;26(1-2):23-6. doi: 10.1159/000118891.
We investigated subsets of peripheral immunologic cells in 12 drug-free patients affected by major depression according to DSM-III-R criteria, and who had recent evidence of somatic diseases. They were compared with 10 drug-free depressives, with 10 patients with panic disorder, and with 12 healthy volunteers, all without somatic disease. The immune subsets were measured by flow cytometry. The results showed that both groups of depressives had the same abnormalities in immune cells compared with the healthy volunteers or the panic disorder patients; in particular they presented a lower number of CD3+, CD8+ and HLA-DR+. The patients with panic attacks did not differ from healthy controls, except for CD4+ cells which were significantly lowered, even in comparison with the depressive groups. These data, although preliminary and in a small sample, suggest that some immune parameters may be influenced by the presence of a major psychiatric disorder.
我们根据《精神疾病诊断与统计手册第三版修订本》（DSM-III-R）标准，对12名无药物治疗的重度抑郁症患者进行了外周免疫细胞亚群的研究，这些患者近期有躯体疾病证据。将他们与10名无药物治疗的抑郁症患者、10名惊恐障碍患者以及12名无躯体疾病的健康志愿者进行比较。通过流式细胞术测量免疫亚群。结果显示，与健康志愿者或惊恐障碍患者相比，两组抑郁症患者的免疫细胞存在相同异常；特别是他们的CD3 +、CD8 +和HLA-DR +数量较低。惊恐发作患者与健康对照组没有差异，除了CD4 +细胞显著降低，即使与抑郁症组相比也是如此。这些数据虽然是初步的且样本量较小，但表明一些免疫参数可能受到主要精神疾病的影响。
